Dopamine increases in striatum do not elicit craving in cocaine abusers unless they are coupled with cocaine cues
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چکیده
منابع مشابه
Cocaine cues and dopamine in dorsal striatum: mechanism of craving in cocaine addiction.
The ability of drugs of abuse to increase dopamine in nucleus accumbens underlies their reinforcing effects. However, preclinical studies have shown that with repeated drug exposure neutral stimuli paired with the drug (conditioned stimuli) start to increase dopamine by themselves, which is an effect that could underlie drug-seeking behavior. Here we test whether dopamine increases occur to con...
متن کاملConcentration and occupancy of dopamine transporters in cocaine abusers with [11C]cocaine and PET.
The concentration (Bmax) of the dopamine transporter (DAT) and the maximum and effective occupancies by cocaine doses of 0.1 mg/kg or 0.05 mg/kg were measured in the striatum of cocaine abusers (n = 12) by using [11C]cocaine as a radiotracer for the DAT and positron emission tomography (PET). Two methods based on a three-compartment model with one binding site (the nonlinear least squares (NLSQ...
متن کاملReduced Metabolism in Brain “Control Networks” following Cocaine-Cues Exposure in Female Cocaine Abusers
OBJECTIVE Gender differences in vulnerability for cocaine addiction have been reported. Though the mechanisms are not understood, here we hypothesize that gender differences in reactivity to conditioned-cues, which contributes to relapse, are involved. METHOD To test this we compared brain metabolism (using PET and ¹⁸FDG) between female (n = 10) and male (n = 16) active cocaine abusers when t...
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Studies were conducted to determine the impact of self-administered cocaine on extracellular striatal dopamine in four rhesus monkeys. The extent to which external cue conditioning contributed to the effects of cocaine and whether there is activation of striatal dopaminergic neurotransmission during drug-seeking behavior was also examined. Microdialysis measurements were made at 2 min intervals...
متن کاملCocaine Abusers Have an Overexpression of -Synuclein in Dopamine Neurons
-Synuclein is a presynaptic protein that has been implicated as a possible causative agent in the pathogenesis of Parkinson’s disease. The native protein is a major component of nigral Lewy bodies in Parkinson’s disease, and full-length -synuclein accumulates in Lewy neurites. Here we present evidence that -synuclein levels are elevated in midbrain dopamine (DA) neurons of chronic cocaine abuse...
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ژورنال
عنوان ژورنال: NeuroImage
سال: 2008
ISSN: 1053-8119
DOI: 10.1016/j.neuroimage.2007.09.059